Vascular Endothelial Growth Factor B (VEGFB) Antibody
292.5€ (80 µl)
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935106861
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name
Vascular Endothelial Growth Factor B (VEGFB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025109
tested applications
ELISA, WB, IHC
Description
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Endothelial Growth Factor B (VEGFB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49765 |
| Alias | VEGF-B,VEGF-related factor,VRF |
| Background | Antibody anti-VEGFB |
| Status | RUO |
Descripción
VEGFB is a member of the VEGF family that primarily regulates vascular growth and energy metabolism VEGFB binds to VEGFR-1 and Neuropilin-1 (NRP1) to control endothelial cell survival without significantly promoting angiogenesis VEGFB is involved in the transport of fatty acids across endothelial cells into tissues like cardiac muscle and skeletal muscle, where it supports energy homeostasis It is critical for maintaining the health of tissues with high metabolic demand, such as the heart and brain Dysregulation of VEGFB has been linked to metabolic disorders, cardiac hypertrophy, and atherosclerosis Elevated VEGFB expression can protect tissues under ischemic conditions by preserving vascular integrity and promoting fatty acid uptake, making it a potential target for therapeutic interventions in cardiovascular diseases and metabolic syndromes
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