Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175058
tested applications
WB, IHC, IF/ICC
Description
Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) Antibody is a Mouse Monoclonal antibody against Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Cell Adhesion Molecule 1 (VCAM1) |
| Host | Mouse |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | V-CAM 1,VCAM-1,INCAM-100,CD106 |
| Background | Antibody anti-VCAM1 |
| Status | RUO |
Descripción
VCAM1 is a transmembrane glycoprotein and member of the immunoglobulin superfamily that plays a key role in cell adhesion, particularly in leukocyte-endothelial interactions during inflammation VCAM1 is expressed on endothelial cells in response to pro-inflammatory cytokines such as TNF-α and IL-1β where it mediates the adhesion and transmigration of leukocytes, including monocytes and lymphocytes, into inflamed tissues VCAM1 interacts with its ligand VLA-4 (integrin α4β1) to facilitate immune cell recruitment during acute and chronic inflammatory responses VCAM1 is implicated in various diseases including atherosclerosis, where it promotes monocyte adhesion to endothelial cells and contributes to plaque formation Elevated VCAM1 levels are also associated with rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders, where persistent inflammation leads to tissue damage VCAM1 serves as a biomarker for endothelial activation and vascular inflammation, making it a potential target for therapeutic interventions aimed at reducing leukocyte recruitment and chronic inflammation
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