Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody
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Description
Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) Antibody is a Rabbit Polyclonal antibody against Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1). Recombinant Human VCAM1 (25-698Aa)Important In Cell-Cell RecognitionAppears To Function In Leukocyte-Endothelial Cell AdhesionInteracts With Integrin Alpha-4/Beta-1 (Itga4/Itgb1) On Leukocytes, And Mediates Both Adhesion And Signal TransductionThe Vcam1/Itga4/Itgb1 Interaction May Play A Pathophysiologic Role Both In Immune Responses And In Leukocyte EmigRation To Sites Of Inflammation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Cell Adhesion Molecule 1 (VCAM1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19320 |
| Gene ID | 7412 |
| NCBI Accession | NP_001069.1, NM_001078.3 |
| OMIM | 192225 |
| Alias | V-CAM 1,VCAM-1,INCAM-100,CD106 |
| Background | Antibody anti-VCAM1 |
| Status | RUO |
Descripción
VCAM1 is a transmembrane glycoprotein and member of the immunoglobulin superfamily that plays a key role in cell adhesion, particularly in leukocyte-endothelial interactions during inflammation VCAM1 is expressed on endothelial cells in response to pro-inflammatory cytokines such as TNF-α and IL-1β where it mediates the adhesion and transmigration of leukocytes, including monocytes and lymphocytes, into inflamed tissues VCAM1 interacts with its ligand VLA-4 (integrin α4β1) to facilitate immune cell recruitment during acute and chronic inflammatory responses VCAM1 is implicated in various diseases including atherosclerosis, where it promotes monocyte adhesion to endothelial cells and contributes to plaque formation Elevated VCAM1 levels are also associated with rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders, where persistent inflammation leads to tissue damage VCAM1 serves as a biomarker for endothelial activation and vascular inflammation, making it a potential target for therapeutic interventions aimed at reducing leukocyte recruitment and chronic inflammation
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