Vascular Cell Adhesion Molecule 1 (VCAM1) Antibody

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935106861

info@markelab.com

Precio

162.5€ (20 µg)

proveedor

Abbexa

reference

abx109405

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) Antibody is a Rabbit Polyclonal antibody against Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1). Recombinant Human VCAM1 (25-698Aa)Important In Cell-Cell RecognitionAppears To Function In Leukocyte-Endothelial Cell AdhesionInteracts With Integrin Alpha-4/Beta-1 (Itga4/Itgb1) On Leukocytes, And Mediates Both Adhesion And Signal TransductionThe Vcam1/Itga4/Itgb1 Interaction May Play A Pathophysiologic Role Both In Immune Responses And In Leukocyte EmigRation To Sites Of Inflammation.

Background

Vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106), is a human protein encoded by the VCAM1 gene. VCAM-1 plays a critical role in interacting with the integrin very late antigen-4 (VLA4).VCAM-1 is responsible for facilitating the adhesion of various immune cells, including lymphocytes, monocytes, eosinophils, and basophils, to the endothelial blood vessel. Additionally, it plays a vital role in signal transduction between leukocytes and endothelial cells, and it has been implicated in the development of conditions such as atherosclerosis and rheumatoid arthritis. Ectodomain release of VCAM-1 is observed in various situations and is often mediated by enzymes like matrix metalloproteinases (MMPs) and ADAMs (A Disintegrin and Metalloproteinase). This release can be triggered by external factors such as calcium ionophores, cytokines, and growth factors. VCAM-1 is also known by the alias CD106

Background

La proteína de adhesión de células vasculares 1, también conocida como molécula de adhesión de células vasculares 1 (VCAM-1) o Cluster de diferenciación 106 (CD106), es una proteína humana codificada por el gen VCAM1. VCAM-1 desempeña un papel fundamental en la interacción de la integrina (VLA4 Very late Antigen-4). VCAM-1 es responsable de facilitar la adhesión de varias células inmunitarias, incluidos linfocitos, monocitos, eosinófilos y basófilos, al vaso sanguíneo endotelial. . Además, desempeña un papel vital en la transducción de señales entre leucocitos y células endoteliales, y se ha implicado en el desarrollo de enfermedades como la aterosclerosis y la artritis reumatoide. La liberación de ectodominio de VCAM-1 se observa en diversas situaciones y, a menudo, está mediada por enzimas como las metaloproteinasas de matriz (MMP) y ADAM (desintegrina A y metaloproteinasa). Esta liberación puede ser provocada por factores externos como ionóforos de calcio, citocinas y factores de crecimiento. VCAM-1 también es conocido con el alias CD106

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Vascular Cell Adhesion Molecule 1 (VCAM1)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA

purity

> 95%

purification

Purified by Protein G.

buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

size 1

20 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

1 mg

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

VCAM1

dry ice

availability

Shipped within 5-10 working days.

alias

V-CAM 1,VCAM-1,INCAM-100,CD106

uniprot id

https://www.uniprot.org/uniprotkb/P19320

gene id

https://www.ncbi.nlm.nih.gov/gene/7412

NCBI accession

NP_001069.1, NM_001078.3

note

This product is for research use only.

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Human Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit

proveedor

Abbexa

reference

abx050229

Tested Applications

ELISA

reactivity

Human

status

RUO

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