proveedor
Abbexareference
abx011267Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) Antibody is a Rabbit Polyclonal antibody for the detection of p65/RELA. Nuclear factor k B (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel,p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purity
≥ 95% (SDS-PAGE)
purification
Purified by immunogen affinity chromatography.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
RELA
dry ice
No
availability
Shipped within 5-12 working days.
uniprot id
note
This product is for research use only.
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