UV excision repair protein RAD23 homolog B (RAD23B) Antibody
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Description
UV excision repair protein RAD23 homolog B (RAD23B) Antibody is a monoclonal Mouse antibody for the detection of RAD23B.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UV excision repair protein RAD23 homolog B (RAD23B) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | U536 |
| Purity | > 95% |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1-2 weeks. For long-term storage, aliquot and store at -20 °C or -80 °C. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54727 |
| Background | Antibody anti-RAD23B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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