Ubiquitin Like With PHD And Ring Finger Domains 1 (UHRF1) Antibody
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Description
UHRF1 Antibody is a Mouse Monoclonal against UHRF1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin Like With PHD And Ring Finger Domains 1 (UHRF1) |
| Host | Mouse |
| Reactivity | Human, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N4X5 |
| Gene ID | 84632 |
| OMIM | 612420 |
| Background | Antibody anti-UHRF1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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UHRF1 antibody
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
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