Ubiquitin-Like Modifier-Activating Enzyme ATG7 (ATG7) Antibody
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Description
Ubiquitin-Like Modifier-Activating Enzyme ATG7 (ATG7) Antibody is a Rabbit polyclonal antibody for the detection of Human Ubiquitin-Like Modifier-Activating Enzyme ATG7 (ATG7).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin-Like Modifier-Activating Enzyme ATG7 (ATG7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95352 |
| Gene ID | 10533 |
| NCBI Accession | NP_001129503.2 |
| Background | Antibody anti-ATG7 |
| Status | RUO |
Descripción
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ATG7 antibody
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport(Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
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