Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody Pair
988€ (5 × 96 tests)
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name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx117435
tested applications
ELISA
Description
UCHL1 Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains the capture antibody and the detection antibody necessary to prepare five 96-well ELISA kit plates.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Reactivity | Human, Mouse, Guinea pig, Cow, Horse, Pig, Dog, Goat, Sheep |
| Assay Data | Capture: Rabbit IgG Polyclonal Detection: Rabbit IgG Polyclonal (Biotin) |
| Assay Type | Sandwich |
| Size 1 | 5 × 96 tests |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Background | Antibody Pair for UCHL1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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