Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (APC)
741€ (100 tests)
741€ (100 tests)
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name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx270537
tested applications
FCM
Descripción del producto
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (APC) is a Mouse Monoclonal Antibody conjugated to APC against Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Availability | Shipped within 5-15 working days. |
| Background | Antibody anti-UCHL1 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Monoclonal |
| Conjugation | APC |
| Dry Ice | No |
| Form | Liquid |
| Host | Mouse |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Isotype | IgG2b Kappa |
| Name | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (APC) |
| Price | 741 |
| Provider | Abbexa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx270537 |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Status | RUO |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Tested Applications | FCM |
Descripcion del producto en español
Background en español
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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