Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
286€ (100 µl)
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104207
tested applications
WB, IHC, IF/ICC
Descripción del producto
Polyclonal Antibody to Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1).
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Availability | Shipped within 5-7 working days. |
| Background | Antibody anti-UCHL1 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Host | Rabbit |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Name | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody |
| Price | 286 |
| Provider | Abbexa |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx104207 |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | WB, IHC, IF/ICC |
| UniProt ID | Q9R0P9 |
Descripcion del producto en español
Background en español
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
Related Products
Human UCHL1(Ubiquitin carboxyl-terminal hydrolase isozyme L1) ELISA Kit
Ver Producto
Mouse UCHL1(Ubiquitin Carboxyl Terminal Hydrolase L1) ELISA Kit
Ver Producto