Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody

286€ (100 µl)
Este producto es parte de UCHL - Ubiquitin C-Terminal Hydrolase L
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286€ (100 µl)

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935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104207
tested applications
WB, IHC, IF/ICC

Descripción del producto

Polyclonal Antibody to Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1).

Documents del producto

Instrucciones
Data sheet
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Especificaciones del producto

AliasHEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1
AvailabilityShipped within 5-7 working days.
BackgroundAntibody anti-UCHL1
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
CategoryPrimary Antibodies
ClonalityPolyclonal
ConjugationUnconjugated
Dry IceNo
FormLiquid
HostRabbit
Immunogen TargetUbiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)
NameUbiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
Price286
ProviderAbbexa
PurificationPurified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
ReactivityMouse
Recommended DilutionWB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Referenceabx104207
Size 1100 µl
Size 2200 µl
Size 31 ml
StatusRUO
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Tested ApplicationsWB, IHC, IF/ICC
UniProt IDQ9R0P9

Descripcion del producto en español

Background en español

UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.

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