Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
819€ (1 ml)
819€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175014
tested applications
WB, IHC, IF/ICC
Descripción del producto
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Availability | Please enquire. |
| Background | Antibody anti-UCHL1 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Host | Mouse |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Name | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody |
| Price | 819 |
| Provider | Abbexa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx175014 |
| Size 1 | 1 ml |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | WB, IHC, IF/ICC |
Descripcion del producto en español
Background en español
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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