Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody

Este producto es parte de UCHL - Ubiquitin C-Terminal Hydrolase L
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637€ (100 µl)

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935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116412
tested applications
ELISA, WB

Description

Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase) Antibody is a Rabbit Polyclonal antibody against Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetUbiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, WB
BufferPBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP09936
Gene ID7345
OMIM191342
AliasHEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1
BackgroundAntibody anti-UCHL1
StatusRUO

Descripción

UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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