Tumor Protein P63 (TP63) Antibody
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Description
Tumor Protein P63 (TP63) Antibody is a Rabbit Monoclonal antibody for the detection of p63.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Protein P63 (TP63) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC-P: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Clone ID | P941 |
| Purification | Purified from rabbit antiserum by proprietary techniques. |
| Size 1 | 40 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 500 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 20 mg/ml BSA and 0.05% NaN3. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 2-8°C. |
| Dry Ice | No |
| UniProt ID | Q9H3D4 |
| Background | Antibody anti-TP63 |
| Status | RUO |
Descripción
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TP63 antibody
TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd(P40), 50kd(P60),63kd(P63) and 73kd(P73L). It is Nuclear stain.
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Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
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