Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Antibody (PE)
429€ (100 tests)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx139233
tested applications
FCM
Description
CD30 Antibody is a Mouse Monoclonal against CD30.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 20 µl/100 µl of whole blood or 106 cells. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user.The content of a vial (2 ml) is sufficient for 100 tests. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG2a Kappa |
| Clone ID | F080 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P28908 |
| Gene ID | 943 |
| Alias | CD30,Ki-1,D1S166E,CD30L receptor,Lymphocyte activation antigen CD30,Tumor necrosis factor receptor superfamily member 8 |
| Background | Antibody anti-TNFRSF8 |
| Status | RUO |
Descripción
TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily Member 8), also known as CD30, is a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily. This family is composed of receptors that play critical roles in modulating immune responses, inflammation, and apoptosis. CD30 is primarily expressed on activated T and B cells, and its expression is upregulated in certain immune-related diseases and cancers, particularly Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). It has emerged as a significant target in cancer immunotherapy and as a diagnostic marker for lymphoma. The receptor is a hallmark of classical Hodgkin lymphoma (cHL) and ALCL due to its overexpression on malignant cells. Beyond cancer, CD30 has implications in the regulation of immune homeostasis, playing a role in T-cell activation, differentiation, and proliferation. Dysregulation of CD30 signaling can lead to chronic inflammation and the development of autoimmune disorders, making it an essential molecule of interest in both oncology and immunology.
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