Tumor Necrosis Factor Receptor Superfamily Member 6 (FAS) Antibody (APC / Cyanine 7)
468€ (100 tests)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 6 (FAS) Antibody (APC / Cyanine 7)
category
Primary Antibodies
provider
Abbexa
reference
abx140978
tested applications
FCM
Description
Tumor Necrosis Factor Receptor Superfamily Member 6 (FAS) Antibody (APC / Cyanine 7) is a Mouse against Tumor Necrosis Factor Receptor Superfamily Member 6 (FAS).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 6 (FAS) |
| Host | Mouse |
| Reactivity | Human |
| Conjugation | APC / Cyanine 7 |
| Isotype | IgG1 |
| Clone ID | E504 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P25445 |
| Gene ID | 355 |
| Alias | APT1,CD95,FAS1,APO-1,FASTM,ALPS1A,TNFRSF6,Apo-1 antigen,Apoptosis-mediating surface antigen FAS,FASLG receptor |
| Background | Antibody anti-FAS |
| Status | RUO |
Descripción
Tumor necrosis factor receptor superfamily member 6 (FAS), also known as CD95, is a cell surface receptor involved in the regulation of apoptosis through the extrinsic pathway FAS belongs to the TNF receptor family and triggers apoptosis upon binding with its ligand, FASL This interaction activates the caspase cascade, leading to programmed cell death FAS-mediated apoptosis plays a critical role in immune system regulation, particularly in eliminating autoreactive T-cells during immune tolerance and in regulating the survival of activated immune cells In addition to immune regulation, FAS signaling is involved in tumor progression, where altered expression of FAS or its ligand can either promote or inhibit cancer cell survival In many cancers, FAS expression is dysregulated, contributing to resistance to apoptosis and enabling tumor cell evasion from immune surveillance FAS has also been implicated in autoimmune diseases, where inappropriate activation or inhibition of FAS signaling can lead to tissue damage and chronic inflammation
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