Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) Antibody (Biotin)
390€ (200 µl)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272971
tested applications
WB, IHC, IF/ICC
Description
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Tumor necrosis factor receptor superfamily member 14,TR2,ATAR,HVEA,HVEM; CD270,LIGHTR,Herpes virus entry mediator A,Tumor necrosis factor receptor-like 2 |
| Background | Antibody anti-TNFRSF14 |
| Status | RUO |
Descripción
TNFRSF14, also known as herpesvirus entry mediator (HVEM), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). Expressed broadly on hematopoietic and non-hematopoietic cells, TNFRSF14 is a transmembrane receptor involved in regulating immune responses. It is a critical component in balancing immune activation and suppression, particularly in T cell regulation, innate immunity, and inflammation. TNFRSF14 interacts with several ligands, including LIGHT (TNFSF14), BTLA (B and T lymphocyte attenuator), and CD160, which engage the receptor in activating or inhibitory roles depending on the context. Due to its role in immune regulation, TNFRSF14 is significant in autoimmune diseases, cancer, and infectious diseases. For example, in autoimmune diseases like multiple sclerosis, TNFRSF14 signaling can contribute to disease pathology through immune cell activation and inflammation. In oncology, TNFRSF14 can act as an immune checkpoint, modulating anti-tumor immunity, making it a target for potential immunotherapy interventions.
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