Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody
494€ (200 µg)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx414847
tested applications
WB, IHC, FCM
Description
Tumor Necrosis Factor Receptor Superfamily Member 12A (CD266) Antibody is a Mouse Monoclonal antibody against Tumor Necrosis Factor Receptor Superfamily Member 12A (CD266).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) |
| Host | Mouse |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purification | Purified |
| Size 1 | 200 µg |
| Form | Liquid |
| Tested Applications | WB, IHC, FCM |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NP84 |
| Gene ID | 51330 |
| Alias | Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14) |
| Background | Antibody anti-TNFRSF12A |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.
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