Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody
741€ (1 ml)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx174980
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NP84 |
| Gene ID | 51330 |
| Alias | Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14) |
| Background | Antibody anti-TNFRSF12A |
| Status | RUO |
Descripción
TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.
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