Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody

Este producto es parte de TNFRSF12A - TNF receptor superfamily member 12A
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299€ (0.1 mg)

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935106861
info@markelab.com
name
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140128
tested applications
WB, IHC, FCM, FUNC

Description

TNFRSF12A Antibody is a Mouse Monoclonal against TNFRSF12A.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A)
Host
Mouse
Reactivity
Human, Mouse
Recommended Dilution
Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2b
Clone ID
M870
Purity
> 95% (SDS-PAGE)
Purification
Purified by Protein A affinity chromatography.
Size 1
0.1 mg
Tested Applications
WB, IHC, FCM, FUNC
Buffer
LE/AF PBS solution, 0.2 µm filter sterilized.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8°C. Do not freeze.
Dry Ice
No
UniProt ID
Q9NP84
Gene ID
51330
Alias
Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
Background
Antibody anti-TNFRSF12A
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.

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