Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) Antibody Pair
988€ (5 × 96 tests)
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Name
Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) Antibody Pair
Category
Antibody Pairs
Provider
Abbexa
Reference
abx117523
Tested Applications
ELISA
Description
TNFRSF10D Antibody Pair for use in Sandwich ELISA assay development.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Antibody Pairs |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) |
| Host | Capture Host: Rabbit Detection Host: Rabbit |
| Reactivity | Human, Pig, Dog |
| Assay Type | Sandwich |
| Clonality | Capture Clonality: Polyclonal Detection Clonality: Polyclonal |
| Conjugation | Biotin |
| Isotype | Capture Isotype: IgG Detection Isotype: IgG |
| Size 1 | 5 × 96 tests |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | Tumor necrosis factor receptor superfamily member 10D,DCR2,CD264,TRUNDD,TRAILR4,TRAIL-R4,Decoy receptor 2,TNF-related apoptosis-inducing ligand receptor 4,(TRAIL receptor 4 |
| Background | Antibody pair for TNFRSF10D |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TNFRSF10D, also known as TRAIL-R4 or DcR2 (Decoy Receptor 2), is a member of the tumor necrosis factor receptor superfamily, specifically binding TRAIL (TNF-related apoptosis-inducing ligand). Unlike apoptosis-inducing TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), TNFRSF10D functions primarily as a “decoy” receptor. It plays a modulatory role by binding TRAIL and potentially preventing TRAIL-induced apoptosis in non-transformed cells. TNFRSF10D is unique among TRAIL receptors in that, while it possesses an intracellular tail with a truncated death domain, it lacks the full ability to transduce apoptotic signals. This feature gives it a protective function, especially in healthy cells where it modulates apoptosis sensitivity. TNFRSF10D is expressed in various normal tissues and has been implicated in protecting these tissues from unwanted TRAIL-mediated apoptosis. It is a subject of considerable interest in the field of cancer biology and immune modulation, as its expression pattern and function influence both tumor immunity and potential cancer cell resistance to TRAIL-based therapies.
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