Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) Antibody Pair

Background

TNFRSF10D, also known as TRAIL-R4 or DcR2 (Decoy Receptor 2), is a member of the tumor necrosis factor receptor superfamily, specifically binding TRAIL (TNF-related apoptosis-inducing ligand). Unlike apoptosis-inducing TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), TNFRSF10D functions primarily as a “decoy” receptor. It plays a modulatory role by binding TRAIL and potentially preventing TRAIL-induced apoptosis in non-transformed cells. TNFRSF10D is unique among TRAIL receptors in that, while it possesses an intracellular tail with a truncated death domain, it lacks the full ability to transduce apoptotic signals. This feature gives it a protective function, especially in healthy cells where it modulates apoptosis sensitivity. TNFRSF10D is expressed in various normal tissues and has been implicated in protecting these tissues from unwanted TRAIL-mediated apoptosis. It is a subject of considerable interest in the field of cancer biology and immune modulation, as its expression pattern and function influence both tumor immunity and potential cancer cell resistance to TRAIL-based therapies.