CD70 Antigen / Tumor Necrosis Factor Ligand Superfamily Member 7 (CD70) Antibody
780€ (1 ml)
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Name
CD70 Antigen / Tumor Necrosis Factor Ligand Superfamily Member 7 (CD70) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx174977
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD70 Antigen / Tumor Necrosis Factor Ligand Superfamily Member 7 (CD70) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32970 |
| Gene ID | 970 |
| Alias | CD27L,LPFS3,CD27-L,CD27LG,TNFSF7,TNLG8A,CD70 antigen,CD27 ligand |
| Background | Antibody anti-CD70 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD70, also known as TNFSF7 (Tumor Necrosis Factor Superfamily Member 7), is a transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) ligand superfamily. It is primarily expressed on the surface of activated immune cells, including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells. The expression of CD70 is tightly regulated and is typically transient, occurring upon immune cell activation, particularly during the adaptive immune response. CD70 plays a crucial role in immune cell interactions, contributing to T cell proliferation, differentiation, and the development of memory T cells. CD70 exerts its effects by binding to its receptor, CD27, which is a member of the TNF receptor superfamily. CD27 is constitutively expressed on naïve T cells, memory T cells, and NK cells, and its interaction with CD70 initiates intracellular signaling pathways that enhance immune activation and memory formation. This CD70-CD27 interaction is critical for effective immune responses, particularly during viral infections, tumor immunity, and in the context of autoimmune diseases.
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