Tumor Necrosis Factor (TNF) Antibody Pair
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Description
Tumor Necrosis Factor (TNF) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Tumor Necrosis Factor (TNF) |
| Reactivity | Dog |
| Assay Data | Detection Antibody Biotinilated |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51742 |
| Gene ID | 403922 |
| Alias | TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin |
| Background | Antibody Pair for TNF |
| Status | RUO |
| Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
Tumor Necrosis Factor (TNF) is a versatile cytokine involvedl in numerous physiological and pathological processes. It holds a critical role in modulating immune responses, inflammation, and apoptosis. While predominantly produced by activated macrophages, TNF can also originate from various cell types like lymphocytes, mast cells, endothelial cells, and fibroblasts. Two well-known forms of TNF are TNF-alpha and TNF-beta, also referred to as lymphotoxin-alpha. TNF-alpha, being extensively studied, exists in both soluble and membrane-bound forms, both capable of initiating biological responses by binding to their respective receptors. TNF signaling operates through two receptors: TNFR1 and TNFR2. TNFR1 is ubiquitously expressed across cell types, whereas TNFR2 is primarily found in endothelial, epithelial, and certain immune cells. TNFR1 signaling typically triggers pro-inflammatory and apoptotic responses, while TNFR2 signaling exhibits anti-inflammatory properties and fosters cell proliferation. In autoimmune disease treatment, suppressing TNFR1 signaling has proved significant, whereas TNFR2 signaling supports wound healing.The primary function of TNF lies in regulating immune cells
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