Tumor Necrosis Factor (TNF) Antibody (Biotin)
proveedor
Abbexareference
abx273434Tested Applications
WB, IHC, IF/ICCreactivity
Monkeystatus
RUOclonality
PolyclonalDescripción
Tumor Necrosis Factor (TNF) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Tumor Necrosis Factor (TNF).
Background
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Background
El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Monkey
immunogen target
Tumor Necrosis Factor (TNF)
host
Rabbit
conjugation
Biotin
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by antigen-specific affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
200 µl
size 2
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
TNF
dry ice
No
availability
Shipped within 5-15 working days.
alias
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
uniprot id
note
This product is for research use only.
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