TNF Antibody is a Rabbit Polyclonal antibody against TNF. TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane proteinMembrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to geneRate a soluble homotrimerBoth membrane and soluble forms of TNF-α are biologically activeTNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophagesCellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological contextActivation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell deathTNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosisThe role of TNF-α in autoimmunity is underscored by blocking TNF-α action to treat rheumatoid arthritis and Crohn’s diseaseThis protein is involved in Immunology.
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Tumor Necrosis Factor (TNF)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TNF
No
Shipped within 5-10 working days.
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
This product is for research use only.
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