Tumor Necrosis Factor (TNF) Antibody

Pida mas información

935106861

info@markelab.com

Precio

300€ (100 µl)

proveedor

Abbexa

reference

abx102796

Tested Applications

WB, IHC, IF/ICC

reactivity

Sheep

status

RUO

clonality

Polyclonal

Descripción

Polyclonal Antibody to Tumor Necrosis Factor (Tumor Necrosis Factor).

Background

Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.

Background

El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.

Características del producto

clonality

Polyclonal

reactivity

Sheep

immunogen target

Tumor Necrosis Factor (TNF)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

WB, IHC, IF/ICC

purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

size 1

100 µl

size 2

200 µl

size 3

1 ml

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

TNF

dry ice

availability

Shipped within 5-12 working days.

alias

TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin

uniprot id

https://www.uniprot.org/uniprotkb/P23383

gene id

https://www.ncbi.nlm.nih.gov/gene/443540

note

This product is for research use only.

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