Tripartite Motif-Containing Protein 5 (TRIM5) Antibody
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Description
TRIM5 Antibody is a Goat Polyclonal antibody against TRIM5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tripartite Motif-Containing Protein 5 (TRIM5) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 85363 |
| NCBI Accession | NP_149023.1, NP_149083.1, NP_149084.1 |
| Background | Antibody anti-TRIM5 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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Human TRIM5 (Tripartite motif-containing protein 5) ELISA Kit
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TRIM5 antibody
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N(also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex(includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus(N-MLV), equine infectious anemia virus(EIAV), simian immunodeficiency virus of macaques(SIVmac), feline immunodeficiency virus(FIV), and bovine immunodeficiency virus(BIV)(PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2(PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction(PubMed:25127057).
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