Trefoil Factor 3 (TFF3) Antibody (HRP)
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Description
Trefoil Factor 3 Antibody is a Rabbit Polyclonal antibody conjugated to HRP against Trefoil Factor 3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Trefoil Factor 3 (TFF3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07654 |
| Gene ID | 7033 |
| NCBI Accession | NP_003217.3 |
| OMIM | 600633 |
| Alias | ABC-C,ABC3,LBM180,SMDP3 |
| Background | Antibody anti-ABCA3 |
| Status | RUO |
Descripción
ABCA3 is a critical protein in pulmonary surfactant production, predominantly expressed in alveolar type II epithelial cells in the lungs. It plays an essential role in transporting phospholipids and cholesterol into lamellar bodies, which are specialized organelles where surfactant is stored before secretion. ABCA3 utilizes ATP hydrolysis to facilitate lipid transport, ensuring the proper composition and function of surfactant, which reduces surface tension in the alveoli and prevents lung collapse. Mutations in the ABCA3 gene are associated with surfactant metabolism disorders, including neonatal respiratory distress syndrome and interstitial lung disease. These conditions are characterized by impaired surfactant production, leading to respiratory failure. ABCA3’s function in lipid transport and its critical role in pulmonary physiology underscore its importance in respiratory health.
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