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Transmembrane Channel-Like Protein 2 (TMC2) Antibody
proveedor
Abbexareference
abx313779Tested Applications
ELISA, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
TMC2 Antibody is a Rabbit Polyclonal against TMC2.
Background
The TMC gene family (TMC1-8) includes transmembrane channel-like (TMC) proteins with crucial cellular functions that can influence ion channels or transporters. TMC1 and TMC2 are founding members and their loss results in hearing and balance issues. TMC1, TMC2, and TMC3 form subfamily expressed at low levels, while TMC4 to TMC8 are more abundantly expressed in various tissues. TMC6 and TMC8 are synonymous with the EVER1 and EVER2 genes associated with epidermodysplasia verruciformis, a recessive disorder linked to susceptibility to cutaneous human papillomavirus infections and related nonmelanoma skin cancers. These genes provide additional avenues for studying the TMC gene family across different genetic and tissue contexts.
Background
La familia de genes TMC (TMC1-8) incluye proteínas similares a canales transmembrana (TMC) con funciones celulares cruciales que pueden influir en los canales iónicos o los transportadores. TMC1 y TMC2 son miembros fundadores y su pérdida provoca problemas de audición y equilibrio. TMC1, TMC2 y TMC3 forman la subfamilia expresada en niveles bajos, mientras que TMC4 a TMC8 se expresan más abundantemente en varios tejidos. TMC6 y TMC8 son sinónimos de los genes EVER1 y EVER2 asociados con la epidermodisplasia verruciforme, un trastorno recesivo relacionado con la susceptibilidad a las infecciones cutáneas por el virus del papiloma humano y a cánceres de piel no melanoma relacionados. Estos genes proporcionan vías adicionales para estudiar la familia de genes TMC en diferentes contextos genéticos y tisulares.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Transmembrane Channel-Like Protein 2 (TMC2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IF/ICC
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
TMC2
dry ice
No
availability
Shipped within 5-10 working days.
uniprot id
NCBI accession
NP_542789.2, NM_080751.2
note
This product is for research use only.
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