Transforming Growth Factor Beta 1 (TGFB1) Antibody
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Description
TGFB1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transforming Growth Factor Beta 1 (TGFB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01137 |
| Alias | CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta |
| Background | Antibody anti-TGFB1 |
| Status | RUO |
Descripción
TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.
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TGFB1 antibody
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).
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TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).
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