Transforming Growth Factor Beta 1 (TGFb1) Antibody
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Transforming Growth Factor Beta 1 (TGFb1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx174870
tested applications
WB, IHC
Description
Transforming Growth Factor Beta 1 (TGFb1) Antibody is a Mouse Monoclonal antibody against Transforming Growth Factor Beta 1 (TGFb1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Transforming Growth Factor Beta 1 (TGFb1) Immunogen: abx069427 - Recombinant TGFb1 (Ala279-Ser390) expressed in E. coli |
| Host | Mouse |
| Reactivity | Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.5-3 µg/ml, IHC: 5-30 µg/ml, IF/ICC (Predicted): 5-30 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17246 |
| Gene ID | 59086 |
| Alias | CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta |
| Background | Antibody anti-TGFB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.
Related Products
Rat Transforming Growth Factor Beta 1 (TGFb1) Protein
Rat Transforming Growth Factor Beta 1 (TGFb1) is a recombinant Rat protein expressed in E. coli.
Ver Producto