Transforming Growth Factor, Beta 1 (TGFB1) Antibody

Este producto es parte de TGFB1 - Transforming Growth Factor Beta 1
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637€ (100 µl)

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935106861
info@markelab.com
name
Transforming Growth Factor, Beta 1 (TGFB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116183
tested applications
ELISA, IHC

Description

Transforming Growth Factor, Beta 1 Antibody is a Rabbit Polyclonal antibody against Transforming Growth Factor, Beta 1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetTransforming Growth Factor, Beta 1 (TGFB1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, IHC
BufferPBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP01137
Gene ID7040
OMIM131300
AliasCED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta
BackgroundAntibody anti-TGFB1
StatusRUO

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

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