Transferrin (TF) Antibody

Product specifications

Primary Antibodies

Transferrin (TF)

Mouse

Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG1

Purified from ascites.

1 mg

Liquid

ELISA

Buffer contains NaN3 as a preservative.

Shipped within 10-20 working days.

Aliquot and store at 2°C to 8°C upon receipt.

No

PRO1557,PRO2086,TFQTL1,HEL-S-71p

Antibody anti-TF

RUO

Descripción

Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.

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