Serotransferrin (TF) Antibody
299€ (0.1 mg)
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Name
Serotransferrin (TF) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139902
Tested Applications
ELISA, WB, IHC, IF/ICC, RIA, FUNC
Description
Serotransferrin Antibody (Azide free) is a Mouse Monoclonal against Serotransferrin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Serotransferrin (TF) Immunogen: Purified porcine Serotransferrin. |
| Host | Mouse |
| Reactivity | Human, Pig, Rabbit |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1-2 μg/ml, IHC-P: 10 μg/ml. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | T589 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | ELISA, WB, IHC, IF/ICC, RIA, FUNC |
| Buffer | Azide free PBS, approx. pH 7.4; 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P02787 |
| Gene ID | 7018 |
| Alias | PRO1557,PRO2086,TFQTL1,HEL-S-71p |
| Background | Antibody anti-TF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.
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