Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
195€ (25 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx412670
Tested Applications
IHC, FCM, IP
Description
Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody is a Rat Monoclonal antibody against Transferrin Receptor Protein 1 / CD71 (TFRC).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transferrin Receptor Protein 1 / CD71 (TFRC) |
| Host | Rat |
| Reactivity | Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 25 µg |
| Size 2 | 100 µg |
| Size 3 | 250 µg |
| Form | Liquid |
| Tested Applications | IHC, FCM, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q62351 |
| Alias | CD71,IMD46,T9,TFR,TFR1,TR,TRFR,p90 |
| Background | Antibody anti-TFRC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TFRC, also known as CD71, is a transmembrane glycoprotein that mediates the uptake of transferrin-bound iron into cells via receptor-mediated endocytosis. It plays a crucial role in iron homeostasis, as iron is essential for processes like DNA synthesis, oxygen transport, and energy metabolism. TFRC expression is tightly regulated by cellular iron levels, proliferative demand, and hypoxia, with high expression observed in rapidly dividing cells, such as activated lymphocytes, erythroid progenitors, and cancer cells. Its overexpression is frequently observed in tumors, where increased iron uptake supports cancer cell proliferation and survival. TFRC is also involved in immune regulation and erythropoiesis, with its deficiency leading to anemia, impaired cell growth, and compromised immune responses. Targeting TFRC is being explored in cancer therapy as a mechanism for selective drug delivery and iron deprivation. Knockdown studies show impaired iron metabolism, reduced cell proliferation, and increased sensitivity to oxidative stress, emphasizing its central role in cellular growth, iron transport, and metabolic regulation.
Productos relacionados
Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody is a Rabbit Polyclonal antibody against Transferrin Receptor Prote…
Ver producto Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
CD71 Transferrin Receptor Antibody is a Mouse monoclonal antibody for human cds against CD71 Transferrin Receptor.…
Ver producto Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
CD71 TRANSFERRIN RECEPT Antibody is a Monoclonal Antibody to Human CDs.…
Ver producto