Transcriptional Enhancer Factor TEF-3 (TEAD4) Antibody
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Description
Transcriptional Enhancer Factor TEF-3 (TEAD4) Antibody is a Rabbit polyclonal antibody for the detection of Human Transcriptional Enhancer Factor TEF-3 (TEAD4).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcriptional Enhancer Factor TEF-3 (TEAD4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15561 |
| Gene ID | 7004 |
| NCBI Accession | NP_003204.2 |
| Background | Antibody anti-TEAD4 |
| Status | RUO |
Descripción
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Human TEAD4 (Transcriptional enhancer factor TEF-3) ELISA Kit
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TEAD4 antibody
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
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