TRAF3 Interacting Protein 2 (TRAF3IP2) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
TRAF3 Interacting Protein 2 (TRAF3IP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433396
tested applications
P-ELISA, WB
Description
TRAF3IP2 Antibody is a Goat Polyclonal antibody against TRAF3IP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: TRAF3 Interacting Protein 2 (TRAF3IP2) Immunogen: abx615270 - Internal region: C-PDTGHDSDKSDQ |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10758 |
| NCBI Accession | NP_679211.1, NP_001157753.1 |
| Alias | Adapter protein CIKS,Connection to IKK and SAPK,JNK,E3 ubiquitin-protein ligase CIKS,CANDF8, CIKS, PSORS13 |
| Background | Antibody anti-TRAF3IP2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
RAF3-interacting protein 2 (TRAF3IP2), also known as Act1, is an adaptor protein that plays a key role in the regulation of inflammatory and immune responses by linking receptors such as IL-17 and CD40 to downstream signaling pathways. It interacts with TRAF family proteins to activate NF-kappa-B, MAPKs, and other transcriptional regulators critical for cytokine production and immune cell activation. TRAF3IP2 is essential for IL-17-mediated signaling, contributing to pro-inflammatory responses in autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. It also regulates B-cell survival and antibody production through interactions with CD40 and BAFF receptor pathways. Dysregulation or mutations in TRAF3IP2 are associated with increased inflammation, immune dysregulation, and susceptibility to certain cancers.
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