TRAF3 interacting protein 1 (TRAF3IP1) Antibody

Background

TRAF3IP1, also known as IFT54, is a signaling adaptor protein that interacts with TRAF3 and participates in immune signaling and intracellular transport processes. It is a critical component of the intraflagellar transport (IFT) machinery, which regulates ciliogenesis and ciliary signaling pathways by mediating the transport of cargo proteins within primary cilia. TRAF3IP1 plays a key role in developmental processes, cell signaling, and tissue homeostasis by facilitating cilia assembly and function. It is expressed in ciliated epithelial tissues, immune cells, and the brain, where it regulates processes such as Hedgehog signaling, immune response, and cytoskeletal organization. Dysregulation or mutations in TRAF3IP1 are associated with ciliopathies, including Joubert syndrome and nephronophthisis, due to defective cilia function and signaling. Knockout studies reveal impaired ciliogenesis, disrupted signaling pathways, and developmental abnormalities, emphasizing its essential role in cilia-mediated signaling and cellular organization.