Topoisomerase I, Mitochondrial (TOP1MT) Antibody
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Description
Topoisomerase I, Mitochondrial Antibody is a Rabbit Polyclonal against Topoisomerase I, Mitochondrial.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Topoisomerase I, Mitochondrial (TOP1MT) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Background | Antibody anti-TOP1MT |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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TOP1MT antibody
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone(By similarity).
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Topoisomerase I, Mitochondrial (TOP1MT) Antibody
Topoisomerase I, Mitochondrial Antibody is a Rabbit Polyclonal against Topoisomerase I, Mitochondrial.
Ver Producto
Topoisomerase I, Mitochondrial (TOP1MT) Antibody
Topoisomerase I, Mitochondrial Antibody is a Rabbit Polyclonal against Topoisomerase I, Mitochondrial.
Ver Producto