Toll Like Receptor 4 (TLR4) Antibody (FITC)

Este producto es parte de TLR4 - toll like receptor 4
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585€ (100 µg)

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935106861
info@markelab.com
name
Toll Like Receptor 4 (TLR4) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx446359
tested applications
WB, IHC, IF/ICC, FCM, FACS

Description

TLR4 Antibody (FITC) is a Rabbit Polyclonal against TLR4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Toll Like Receptor 4 (TLR4)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500, IHC: 1/50. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
FITC
Purification
Purified by Protein A.
Size 1
100 µg
Tested Applications
WB, IHC, IF/ICC, FCM, FACS
Buffer
PBS, 50% glycerol, 0.09% sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O00206
Gene ID
7099
NCBI Accession
NP_612564.1
Alias
Toll-like receptor 4,TOLL,CD284,TLR-4,ARMD10,hToll
Background
Antibody anti-TLR4
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

Toll-like receptor 4 (TLR4) is a member of the toll-like receptor family of proteins, which play crucial roles in the innate immune system. TLR4 is well-known for its capacity to detect lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, which is a pathogen-associated molecular pattern (PAMP) that signals the presence of bacterial infections. Upon binding to LPS, TLR4 triggers a cascade of immune responses, including the activation of nuclear factor-kappa B (NF-κB) and the production of pro-inflammatory cytokines. These responses lead to a rapid immune reaction, making TLR4 essential for the early detection and management of bacterial infections. TLR4 is expressed in various cell types, including macrophages, dendritic cells, epithelial cells, and endothelial cells. The receptor is unique among TLRs due to its ability to signal through two distinct adaptor pathways: MyD88-dependent and TRIF-dependent pathways, which allows TLR4 to activate a broad array of immune responses. While critical in defense against infection, excessive or dysregulated TLR4 activation can contribute to chronic inflammation, autoimmune disorders, and septic shock, making TLR4 a target of interest for both enhancing and dampening immune responses therapeutically.

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