TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody
377€ (100 µg)
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Name
TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx233017
Tested Applications
ELISA, WB, IHC, FCM
Description
FAS/CD95 Antibody is a Mouse Monoclonal against FAS/CD95.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Immunogen: Fas (TNF receptor superfamily, member 6) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/1000 - 1/8000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | Y559 |
| Observed MW | Observed MW: 38-45 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25445 |
| Alias | APT1,CD95,FAS1,APO-1,FASTM,ALPS1A,TNFRSF6,Apo-1 antigen,Apoptosis-mediating surface antigen FAS,FASLG receptor |
| Background | Antibody anti-FAS |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Tumor necrosis factor receptor superfamily member 6 (FAS), also known as CD95, is a cell surface receptor involved in the regulation of apoptosis through the extrinsic pathway FAS belongs to the TNF receptor family and triggers apoptosis upon binding with its ligand, FASL This interaction activates the caspase cascade, leading to programmed cell death FAS-mediated apoptosis plays a critical role in immune system regulation, particularly in eliminating autoreactive T-cells during immune tolerance and in regulating the survival of activated immune cells In addition to immune regulation, FAS signaling is involved in tumor progression, where altered expression of FAS or its ligand can either promote or inhibit cancer cell survival In many cancers, FAS expression is dysregulated, contributing to resistance to apoptosis and enabling tumor cell evasion from immune surveillance FAS has also been implicated in autoimmune diseases, where inappropriate activation or inhibition of FAS signaling can lead to tissue damage and chronic inflammation