TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody
299€ (0.1 mg)
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Name
TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139049
Tested Applications
IHC, FCM
Description
CD95 Antibody is a Mouse Monoclonal against CD95.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Immunogen: HUT-78 Human T cell lymphoma cell line. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | E504 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P25445 |
| Gene ID | 355 |
| Alias | APT1,CD95,FAS1,APO-1,FASTM,ALPS1A,TNFRSF6,Apo-1 antigen,Apoptosis-mediating surface antigen FAS,FASLG receptor |
| Background | Antibody anti-FAS |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Tumor necrosis factor receptor superfamily member 6 (FAS), also known as CD95, is a cell surface receptor involved in the regulation of apoptosis through the extrinsic pathway FAS belongs to the TNF receptor family and triggers apoptosis upon binding with its ligand, FASL This interaction activates the caspase cascade, leading to programmed cell death FAS-mediated apoptosis plays a critical role in immune system regulation, particularly in eliminating autoreactive T-cells during immune tolerance and in regulating the survival of activated immune cells In addition to immune regulation, FAS signaling is involved in tumor progression, where altered expression of FAS or its ligand can either promote or inhibit cancer cell survival In many cancers, FAS expression is dysregulated, contributing to resistance to apoptosis and enabling tumor cell evasion from immune surveillance FAS has also been implicated in autoimmune diseases, where inappropriate activation or inhibition of FAS signaling can lead to tissue damage and chronic inflammation
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