TNF Receptor-Associated Factor 3 (TRAF3) Antibody (Biotin)
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Description
TRAF3 Antibody (Biotin) is a Rabbit Polyclonal against TRAF3 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | TNF Receptor-Associated Factor 3 (TRAF3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13114 |
| Gene ID | 7187 |
| NCBI Accession | NP_001186356.1, NM_001199427.1, NP_003291.2, NM_003300.3 |
| OMIM | 601896 |
| Alias | TRAF-3,TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118 |
| Background | Antibody anti-TRAF3 |
| Status | RUO |
Descripción
TRAF3 is an adaptor protein that regulates signaling downstream of receptors like CD40, BAFF-R, and Toll-like receptors (TLRs), playing a crucial role in immune regulation, lymphocyte activation, and antiviral responses. Unlike TRAF1 and TRAF2, TRAF3 functions as a negative regulator of the non-canonical NF-κB pathway by targeting NIK (NF-κB-inducing kinase) for degradation, thereby preventing constitutive activation of NF-κB2 signaling. TRAF3 is widely expressed in immune cells, where it regulates B-cell survival, interferon production, and immune tolerance. Dysregulation of TRAF3 is associated with B-cell malignancies, autoimmune diseases, and viral infections due to uncontrolled NF-κB activation and impaired immune signaling. Functional studies in knockout models demonstrate defects in B-cell homeostasis, increased susceptibility to autoimmunity, and reduced antiviral immunity, underscoring its dual role in restraining excessive signaling and supporting immune regulation.
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TRAF3 antibody
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
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