TNF Ligand Receptor Superfamily Member 12A Protein

Este producto es parte de TNFRSF12A - TNF receptor superfamily member 12A
Product Graph
234€ (5 µg)

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935106861
info@markelab.com
name
TNF Ligand Receptor Superfamily Member 12A Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx260696
tested applications
SDS-PAGE

Description

TNF Ligand Receptor Superfamily Member 12A Protein is a recombinant cytokine.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
TNFRSF12A
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 97% (SDS-PAGE and RP-HPLC)
Size 1
5 µg
Size 2
25 µg
Size 3
1 mg
Form
Lyophilized 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
UniProt ID
Q9NP84
Alias
Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
Background
Protein TNFRSF12A
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.

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