Tissue Factor (TF) Antibody Pair
1365€ (5 × 96 tests)
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name
Tissue Factor (TF) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370347
tested applications
ELISA
Description
Tissue Factor (TF) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Tissue Factor (TF) |
| Reactivity | Rabbit |
| Assay Data | Detection Antibody Biotinilated |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Shipped within 5-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | TF,TFA,CD142,Coagulation factor III,Thromboplastin |
| Background | Antibody Pair for F3 |
| Status | RUO |
| Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
Coagulation Factor III, also known as Tissue Factor (F3), is a critical glycoprotein in the initiation of the extrinsic pathway of the coagulation cascade. It acts as a receptor and cofactor for Factor VIIa, forming a complex that activates Factor X, which in turn leads to thrombin generation and clot formation. Tissue Factor is highly expressed in subendothelial tissues and is exposed upon vascular injury, where it serves as the primary trigger for hemostasis. Beyond its role in coagulation, F3 also participates in various signaling pathways, influencing inflammation, angiogenesis, and cancer progression through its interaction with protease-activated receptors (PARs). Dysregulation of Tissue Factor expression is associated with pathological conditions such as thrombosis, atherosclerosis, and malignancies. The study of F3 and its interactions, including its structure and binding properties, is crucial for developing targeted anticoagulant therapies and understanding its role in disease mechanisms. Its activity is often analyzed using advanced biochemical assays to elucidate its functions in both normal and pathological states.
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