Tissue Factor Pathway Inhibitor (TFPI) Antibody
377€ (100 µg)
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Name
Tissue Factor Pathway Inhibitor (TFPI) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx238634
Tested Applications
ELISA, WB
Description
TFPI Antibody is a Rabbit Polyclonal against TFPI.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tissue Factor Pathway Inhibitor (TFPI) Immunogen: tissue factor pathway inhibitor |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 30 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10646 |
| Alias | EPI, LACI, TFI, TFPI1,Extrinsic pathway inhibitor,EPI |
| Background | Antibody anti-TFPI |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Tissue Factor Pathway Inhibitor (TFPI) is a crucial regulator of the extrinsic coagulation cascade, primarily inhibiting the tissue factor (TF)-factor VIIa complex and factor Xa to maintain hemostasis and prevent excessive thrombosis. It is a Kunitz-type serine protease inhibitor, produced mainly by endothelial cells, and circulates bound to lipoproteins or as a free plasma protein. TFPI acts as a feedback inhibitor that ensures balanced thrombin generation, thereby reducing the risk of pathological clot formation. Dysregulation or deficiency in TFPI has been linked to thrombotic disorders and cardiovascular diseases. Beyond its anticoagulant role, TFPI exhibits anti-inflammatory properties, reducing vascular inflammation and protecting against atherosclerosis. It is also involved in angiogenesis and endothelial cell function, making it significant in vascular biology.
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