Tislelizumab

Tislelizumab

Pida mas información

935106861

info@markelab.com

Precio

375€ (100 µg)

proveedor

Abbexa

reference

abx831438

Tested Applications

ELISA, WB

reactivity

Human

status

This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications (RUO

clonality

Monoclonal

Descripción

Tislelizumab is a monoclonal antibody biosimilar expressed in CHO cells, targeting PDCD1/PD1/CD279, Tislelizumab (BeiGene) is a humanized monoclonal antibody that was designed to bind to the PD-1 receptor and prevent binding of PD-L1. In addition, tislelizumab was designed to minimize binding to Fc-gamma-receptors (FcyR) on macrophages. Preclinical studies found that binding to FcyR on macrophages compromises the anti-tumor activity of PD-1 antibodies through activation of antibody-dependent macrophage-mediated killing of T effector cells.

Características del producto

category

Biosimilars


host

Human


clonality

Monoclonal


reactivity

Human


immunogen target

PDCD1/PD1/CD279


host

Human


isotype

IgG4 Kappa


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


size 1

100 µg


size 2

1 mg


expression

Recombinant


purity

> 95%


purification

Purified from cell culture supernatants by Protein A/G chromatography.


buffer

0.01 M PBS. pH 7.4.


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


dry ice

No


availability

Shipped within 7-12 working days.


alias

Biosimilars


note

CAS Number 1858168-59-8


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