Thyrotropin Receptor (TSHR) Antibody
221€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Thyrotropin Receptor (TSHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx413194
Tested Applications
ELISA, IHC
Description
Thyrotropin Receptor (TSHR) Antibody is a Mouse Monoclonal antibody against THYROID STIMULATING HORMONE RECEPTOR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Thyrotropin Receptor (TSHR) |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1.0 mg/ml |
| Recommended Dilution | Validated in IHC-F and IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 20 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16473 |
| Alias | TSHR,Thyrotropin Receptor,LGR3,TSH-R,CHNG1,hTSHR-I |
| Background | Antibody anti-TSHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TSHR is a G protein-coupled receptor activated by thyroid-stimulating hormone (TSH), a pituitary hormone that regulates thyroid gland growth and function. TSHR is primarily expressed on thyroid follicular cells, where its activation stimulates the production and release of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). TSHR signaling occurs via Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and stimulation of thyroid hormone synthesis, iodide uptake, and cell proliferation. TSHR plays a critical role in maintaining metabolic homeostasis, thermoregulation, and growth. Dysregulation of TSHR signaling is associated with thyroid disorders, such as Graves' disease (autoimmune hyperthyroidism), where TSHR autoantibodies lead to excessive hormone production, and hypothyroidism caused by receptor mutations. TSHR is also a target in thyroid cancers, where its overactivation promotes tumor growth. TSHR agonists and antagonists are being explored for therapeutic applications in thyroid dysfunction and thyroid-related cancers. TSHR is central to thyroid hormone regulation and overall metabolic balance.
Productos relacionados
Thyrotropin Receptor (TSHR) Antibody
TSHR Antibody is a Rabbit Polyclonal antibody against TSHR. The protein encoded by this gene is a membrane protein and a…
Ver producto
Human Thyroid Stimulating Hormone Receptor (TSHR) ELISA Kit
Human Thyroid Stimulating Hormone Receptor (TSHR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of…
Ver producto Human Anti-Thyroid Stimulating Hormone Receptor Antibody (Anti-TSHR) ELISA Kit
Human Anti-Thyroid Stimulating Hormone Receptor Antibody (Anti-TSHR) ELISA Kit is an ELISA Kit for the in vitro quantita…
Ver producto