Thyroid Hormone Receptor Beta (THRB) Antibody

Product specifications

Primary Antibodies

Target: Thyroid Hormone Receptor Beta (THRB)
Immunogen: abx615232 - Internal region: C-DIGSAPIVNAPEGNKVD

Goat

Zebrafish

Concentration: 0.5 mg/ml

P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

200 µl

Liquid

P-ELISA, WB

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

NP_571415.1

TRb,GRTH,PRTH,THR1,ERBA2,NR1A2,THRB1,THRB2,Trbeta,THRbeta,TRbeta1,C-ERBA-2,THRbeta1,Thrbeta2,C-ERBA-BETA,Nuclear receptor subfamily 1 group A member 2

Antibody anti-THRB

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Thyroid hormone receptor beta (THRB) is another member of the thyroid hormone receptor family, responsible for mediating the effects of thyroid hormones on gene expression Like THRA, THRB binds to thyroid hormones, primarily triiodothyronine (T3), and regulates the expression of genes involved in metabolism, development, and growth THRB is highly expressed in tissues such as the liver, kidney, and heart, where it plays a central role in regulating metabolic processes, including carbohydrate metabolism, lipid metabolism, and cholesterol homeostasis The receptor also influences the development of the central nervous system, particularly in processes like neuronal differentiation and maturation Mutations in THRB can cause a variety of thyroid-related disorders, including the thyroid hormone resistance syndrome, which leads to clinical features such as goiter, heart problems, and developmental delays in children In addition, THRB is implicated in cardiovascular health, where its dysfunction can contribute to arrhythmias, and in metabolic diseases, such as obesity and diabetes, due to its critical role in regulating energy metabolism and glucose homeostasis

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