Thyroid Hormone Receptor Beta (THRB) Antibody
357.5€ (100 µg)
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Name
Thyroid Hormone Receptor Beta (THRB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx145025
Tested Applications
ELISA, WB
Description
THRB Antibody is a Rabbit Polyclonal against THRB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Thyroid Hormone Receptor Beta (THRB) Immunogen: Recombinant fragment corresponding to 11-210 AA of human THRB. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 54 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC106929 |
| Alias | TRb,GRTH,PRTH,THR1,ERBA2,NR1A2,THRB1,THRB2,Trbeta,THRbeta,TRbeta1,C-ERBA-2,THRbeta1,Thrbeta2,C-ERBA-BETA,Nuclear receptor subfamily 1 group A member 2 |
| Background | Antibody anti-THRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Thyroid hormone receptor beta (THRB) is another member of the thyroid hormone receptor family, responsible for mediating the effects of thyroid hormones on gene expression Like THRA, THRB binds to thyroid hormones, primarily triiodothyronine (T3), and regulates the expression of genes involved in metabolism, development, and growth THRB is highly expressed in tissues such as the liver, kidney, and heart, where it plays a central role in regulating metabolic processes, including carbohydrate metabolism, lipid metabolism, and cholesterol homeostasis The receptor also influences the development of the central nervous system, particularly in processes like neuronal differentiation and maturation Mutations in THRB can cause a variety of thyroid-related disorders, including the thyroid hormone resistance syndrome, which leads to clinical features such as goiter, heart problems, and developmental delays in children In addition, THRB is implicated in cardiovascular health, where its dysfunction can contribute to arrhythmias, and in metabolic diseases, such as obesity and diabetes, due to its critical role in regulating energy metabolism and glucose homeostasis
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