Thyroid Hormone Receptor Alpha (THRa) Antibody
286€ (100 µl)
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Name
Thyroid Hormone Receptor Alpha (THRa) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx128070
Tested Applications
WB, IHC, IF/ICC
Description
Thyroid Hormone Receptor Alpha Antibody is a Rabbit Polyclonal against Thyroid Hormone Receptor Alpha.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Thyroid Hormone Receptor Alpha (THRa) Immunogen: THRa (Met1-Pro490) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10827 |
| Alias | AR7,EAR7,ERBA,ERBA1,NR1A1,THRA1,THRA2,c-erbA,ERB-T-1,Tralpha,THRalpha,TRalpha1,TRalpha2,c-ERBA-1,THRalpha1,THRalpha2,Nuclear receptor subfamily 1 group A member 1,V-erbA-related protein 7 |
| Background | Antibody anti-THRA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Thyroid hormone receptor alpha (THRA) is a nuclear receptor that mediates the effects of thyroid hormones (T3 and T4) by regulating gene expression THRA exists in multiple isoforms, which are generated through alternative splicing and have tissue-specific functions The receptor plays a crucial role in the development, growth, and metabolism of various tissues, including the brain, heart, and muscles THRA regulates cellular processes such as metabolism, thermogenesis, and lipid metabolism by influencing the transcription of target genes involved in these pathways The receptor also has a vital role in the development of the nervous system, particularly during fetal and postnatal development Mutations in THRA can lead to various thyroid-related disorders, including resistance to thyroid hormone (RTH), where tissues become less responsive to thyroid hormones, resulting in elevated thyroid hormone levels and metabolic disturbances Additionally, THRA dysregulation has been implicated in certain cancers, where altered thyroid hormone signaling can contribute to tumor growth and progression
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